The anti-acid and alkali fabric is made of polyester-cotton blended fabric or 100% natural synthetic fiber fabric after finishing with new anti-acid and alkali technology and new methods. It overcomes the shortcomings of the original acid-proof fabric using rubber or plastic as the base material, such as airtightness, bulkiness, and poor comfort. The acid-proof fabric treated by this new acid-proof process has good air permeability, softness and lightness, comfortable and easy to wear. Advantages such as washing, suitable for working environment with mild to moderate acidity and alkalinity. It can effectively avoid the splashing and penetration of acid and alkali liquid on the human body, and has excellent performance of long acid penetration resistance and high acid pressure resistance, and is suitable for use by operators who have been exposed to acid and alkali for a long time. Its quality and protective performance have been tested by the National Labor Protection Products Quality Inspection Center to meet the performance requirements of the national GB12012 "acid-proof work clothes", and at the same time can meet the requirements of the European Union EN13034 and EN368 standards.